Application deadline: 23.02.2025
Shape the Future of Pain Research with Us
The clinical research group KFO5001 ResolvePAIN of the German Research Foundation (DFG) is starting the second funding period. It is conducted by clinical and basic scientists from the University Hospital Würzburg, University of Leipzig, and Charité. Principal investigators are based in neurology, anesthesia, psychiatry, neuroradiology, internal medicine, physiology, and clinical neurobiology.
Resolution of and recovery from neuropathic pain depend on mechanisms such as resolution of inflammation, synaptic reorganization, and restoration of neuronal pathways. In ResolvePAIN, we aim to investigate recovery patterns and mechanisms of pain resolution in the peripheral somatosensory and in connection with the central nervous system. We will utilize a combined translational approach involving clinical, preclinical, and basic sciences as well as studies on CNS control over the peripheral processes. Learn more about our work here.
The University Hospital Würzburg will offer from April 1st 2025, or later 4 PhD positions (m/f/d) in fulltime.
We offer
- Structured Doctoral Program: You will be enrolled in the Graduate School of Life Sciences (GSLS) with structured onboarding, personalized milestones, and clear career development paths.
- State-of-the-Art Facilities: Work in excellently equipped labs with cutting-edge technologies like ultra-high field 7T MRI, advanced imaging, and electrophysiology.
- Interdisciplinary Environment: Collaborate with experts from diverse fields, fostering a dynamic and inspiring research atmosphere.
- Work-Life Balance: We support part-time work, remote work options, and offer assistance with childcare and accommodation if needed.
- Career Development: Benefit from specialized scientific training, soft skills workshops, and opportunities for active participation in shaping your research environment.
Your Tasks
PhD topics are
- H. Rittner/R. Kittel: Presynaptic and peripheral plasticity of nociceptors in pain resolution (DOI: 10.7554/eLife.56738; DOI: 10.1038/s41467-023-38575-6) This project employs high resolution imaging to analyze skin and spinal cord plasticity. Experiences in preclinical pain research or imaging are welcome.
- K. Doppler: Neuropathic pain induced by anti Caspr2 autoantibodies: pathogenesis and resolution (Greguletz, Ploetz et al., Different pain phenotypes are associated with anti-Caspr2 autoantibodies. J Neurol 2024, doi: 10.1007/s00415-024-12224-4). In this project, incubation of primary neuron cultures (DRG) and transfected HEK293 with autoantibodies will be applied to investigate functional effects of autoantibodies of different IgG subclasses and their resolution.
- C. Villmann: Neuropathic pain induced by anti Caspr2 autoantibodies: pathogenesis and resolution (Habib et al., Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability. doi: 10.1101/2024.09.04.611282). The project uses high-resolution imaging techniques, transcriptome analysis, and electrophysiological recordings at cellular level to identify signal transduction pathways involved in pain.
- G. Hein: Brain stem circuits for pain regulation and resolution. (DOI: 10.3389/fpsyt.2020.00333) In this project we use ultra-high field 7T functional neuroimaging and computational modeling to investigate the effects of learning and social influence on chronic and acute pain. Experiences with computational modeling and/ or functional magnetic resonance imaging are a big plus. Applications for a PhD or a postdoc position are welcome.
You will find a highly motivated team. Open communication culture is what sets us apart. You will be associated with the doctoral program of the Gradual School of Life Sciences. The programme is characterised by structured onboarding at an excellently equipped workplace and jointly developed milestones and career paths. In addition to a specialised training programme, you can expect skills training and opportunities for co-determination.
As a family-friendly research group, part-time work and working from home as well as support in caring for children or relatives are a matter of course for us. If necessary, we will support you in finding accommodation and childcare. Disabled people will be given priority if they are equally qualified.
Your Profile
Do you fit to us?
You are an open-minded, enthusiastic, committed and research-loving scientist (Master in Neurosciences, Biomedicine, Biology, Biochemistry, Psychology, etc.) having completed your studies above average. You thrive in international teams and translational research. We expect you to work independently with a lively commitment within the KFO5001, resilience and flexibility.
