Update on the progress of IMI-PainCare, a public-private partnership supported by the European Union to improve the care of patients with acute or chronic pain. EFIC is one of about 40 partners of this consortium (www.imi-paincare.eu):
The IMI-PainCare consortium met again, this time for a 2-days scientific conference to stimulate intense scientific exchange among its members. The meeting was hosted by the EFPIA partner TEVA Pharmaceuticals at their side in Netanya (Israel), and more than 45 members attended in person and additional 62 members joined on-line.
The progress made by the three subprojects PROMPT, BioPain and TRiPP and their exciting results of preclinical, translational and clinical studies were reported and vividly discussed in plenary sessions. Further information was provided on 17 posters, whose titles are provided below. For a deep dive into the scientific details, the 2-hour poster session and moreover the coffee breaks were utilized. Emphasis was put on exchanging knowledge and synergizing in the field of preclinical models in chronic pain, which are developed and validated in the BioPain and TRiPP subprojects. Comprehensive discussions were stimulated by the presentations which covered e.g. “Preclinical disease models for endometriosis and Interstitial Cystitis/Bladder Pain Syndrome“, Multi-Center Analysis of Spontaneous Behaviour in Pre-Clinical Models of endometriosis using HomeCageAnalysis systems”, and “Preclinical functional biomarkers spanning the nociceptive system”. Modulation of laser evoked potentials by Lacosamide, Pregabalin & Tapentadol in awake rats .Those were combined with patient characterizations by patient report outcome measures, physiological, or quantitative sensory testing and direct translational analysis of molecular marker between patients and models.
Another overarching theme of all three subprojects was the use of Patient Reported Outcomes (PROMs) in clinical trials. An intensive exchange took place about PROMS used in randomized controlled or open label trials in patients suffering from endometriosis as well as PROMs used in functional biomarker studies in healthy subjects. Part of the discussion was a critical evaluation of the complexity and controversy of PROMS in chronic pelvic pain. A highlight of the meeting was the talk by Jane Meijlink, who represents the partner patient organization International Painful Bladder Foundation. Jane gave an excellent overview of the classification of Interstitial Cystitis / Bladder Pain Syndrome.
Overall, the meeting improved our understanding of pain related diseases, suitable biomarkers and promising translational options, and the use of PROMs in patients with pain and in healthy subjects.
List of Posters presented during the consortium meeting:
PROMPT NIT1: Setting up and implementing a multiple languages, multi-center PROMs survey Claudia Weinmann, Marcus Komann, Winfried Meissner
IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET) Z. Nochi, H. Pia, P. Bloms-Funke, I. Boesl, O. Caspani, S. C. Chapman, F. Fardo, B. Genser, M. Goetz, A. V. Kostenko, C. Leone, T. Li, A. Mouraux, B. Pelz, E. Pogatzki-Zahn, A. Schilder, E. Schnetter, K. Schubart, A. Stouffs, I. Tracey, I. F. Troconiz, A. Truini, J. Van Niel, J. Miguel Vela, K. Vincent, J. Vollert, V. Wanigasekera, M. Wittayer, H. Tankisi, N. B. Finnerup , K. G. Phillips and Rolf-Detlef Treede
IMI2-PainCare-BioPain-RCT2: A randomized, double-blind, placebo-controlled, cross-over, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Preliminary results on test-retest reliability Leone C, Di Stefano G, Di Pietro G, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Finnerup NB, Garcia-Larrea L, Li T, Goetz M, Mouraux A, Pelz B, Pogatzki-Zahn E, Schilder A, Schnetter E, Schubart K, Tracey I, Troconiz IF, Van Niel H, Hernandez JMV, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Truini A, Treede RD
Assessment of Dyspareunia in Pre-Clinical Models of Endometriosis and IC/BPS: a Systematic Review P. Nunez-Badinez et al; Razneen Shah, Lysimachi Demetriou, Bianca De Leo, Nicole Schmidt, Jane Meijlink, Judy Birch, Lone Hummelshoj, Jens Nagel, Katy Vincent
Objectively tracked activity is not correlated with patient-reported pain treatment outcomes one week after surgery Marcus Komann, Claudia Weinmann, Winfried Meißner
Modulation of laser evoked potentials (LEPs) by lacosamide, pregabalin & tapentadol in awake rats Anthony Blockeel, Anna Sales, Sonya Chapman, Kimberley Jackson, Nicolás Marco-Ariño, Iñaki Trocóniz, Josep-Maria Cendros, Jose Miguel Vela, Anthony Pickering, Andrea Truini, Andre Mouraux, Rolf-Detlef Treede& Keith Phillips
Characterisation of the neural correlates of central sensitisation induced by the high frequency stimulation (HFS) model in healthy humans using functional magnetic resonance imaging (fMRI) Sophie Clarke, Vishvarani Wanigasekera, Richard Rogers, Francesca Fardo, Hossein Pia, Zahra Nochi, Nicolas Macian, Vincent Leray, Nanna Brix Finnerup, Gisèle Pickering, André Mouraux, Andrea Truini, Rolf-Detlef Treede and Irene Tracey
Perception threshold tracking (PTT) – A novel method to assess small fiber function Hossein Pia, Zahra Nochi, Bernhard Pelz, Marcus Goetz, Jan Hoeink, Rolf-Detlef Treede, Tony Blockeel, Keith Phillips, Nanna Brix Finnerup, Hatice Tankisi
Analysis of Rat Ultrasonic Vocalizations in a Preclinical Model for Inflammatory Pain Paulina Nunez-Badinez, Bianca De Leo, Alexis Laux-Biehlmann, Katy Vincent, Jens Nagel
Exploring pelvic pain and quality of life profiles in the Translational Research in Pelvic Pain (TRiPP) cohort Lysia Demetriou, Michal Krassowski, Pedro Abreu Mendes, Kurtis Garbutt, Allison Vitonis, Elizabeth Wilkins, Lydia Coxon, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Claire E Lunde, Jane Meijlink, Danielle Perro, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent
What drinking water tells us about bladder sensitivity in Chronic Pelvic Pain Lydia Coxon, Emily Tan, Danielle Perro, Claire Lunde, Joana Ferreira Gomes, Ana Charrua Cordeiro, Pedro Abreu Mendes, Jane Meijlink, Anja Hoffman, Judy Birch, Lone Humnelshoj, Qasim Aziz, Lars Arendt-Nielsen, Esther Pogatzki-Zahn Jan Vollert, Michal Krassowski, Emma Evans, Rolf-Detlef Treede, Lysimachi Demetriou, Stacey Missmer, Andrew Horne, Christine Sieberg, Fransisco Cruz, Jens Nagel, Katy Vincent
Is conditioned pain modulation (CPM) a useful paradigm in women? A TRiPP study exploring CPM in pain-free women and those living with chronic pelvic pain Danielle Perro, Lydia Coxon, Claire Lunde, Joana Ferreira Gomes, Ana Charrua, Pedro Abreu Mendes, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Lysia Demetriou, Kurtis Garbutt, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Michal Krassowski, Jane Meijlink, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Allison Vitonis, Jan Vollert, Christian Becker, Franscisco Cruz, Christine Sieberg, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent, on behalf of the TRiPP Consortium
Understanding Fatigue in Chronic Pelvic Pain patients: a Translational Research in Pelvic Pain (TRiPP) study Lysia Demetriou, Lydia Coxon, Danielle Perro, Pedro Abreu Mendes, Claire E Lunde, Kurtis Garbutt, Michal Krassowski, Allison Vitonis, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne , Anja Hoffman, Lone Hummelshoj, , Jane Meijlink, Danielle Perro, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent
Have you ever had a flare of your symptoms? Clinically important findings from under-explored FLARES in Chronic Pelvic Pain Lydia Coxon, Celia Lugt, Danielle Perro, Claire Lunde, Joana Ferreira Gomes, Ana Charrua Cordeiro, Pedro Abreu Mendes, Judy Birch, Jane Meijlink, Lone Humnelshoj, Anja Hoffmann, Qasim Aziz, Lars Arendt-Nielsen, Esther Pogatzki-Zahn, Jan Vollert, Michal Krassowski, Emma Evans, Rolf-Detlef Treede, Lysimachi Demetriou, Stacey Missmer, Andrew Horne, Christine Sieberg, Fransisco Cruz, Jens Nagel, Katy Vincent
Widespread pain is associated with poor psychological health, sleep quality, fatigue, and pain catastrophizing in women with chronic pelvic pain: A TRiPP study Danielle Perro, Lysia Demetriou, Lydia Coxon, Michal Krassowski, Pedro Abreu Mendes, Claire E Lunde, Kurtis Garbutt, Allison Vitonis, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne , Anja Hoffman, Lone Hummelshoj, Jane Meijlink, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent, on behalf of the TRiPP Consortium
The relationship between pain experience and personality factors in women living with chronic pelvic pain Emma Evans, Lysia Demetriou, Lydia Coxon, Danielle Perro, Pedro Abreu Mendes, Claire E Lunde, Kurtis Garbutt, Michal Krassowski, Allison Vitonis, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne, Anja Hoffman, Lone Hummelshoj, , Jane Meijlink, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent
Multi-Center Analysis of Spontaneous Behaviour in Pre-Clinical Models of ENDO using HCA systems P. Nunez-Badinez, Bianca De Leo, Nicole Schmidt, Philippa TK Saunders, Florent Barthas, Patrick Sweeney, Douglas J Armstrong, Rowland Sillito, Miguel Angel Tejada, Raul Gomez, Katy Vincent, Jens Nagel
